What is included in the cruise fare?

Standard cruise fares include your cabin, onboard meals at main dining venues, most non-specialty entertainment, use of pools and common facilities, and transport between ports of call. Gratuities, specialty dining, alcoholic drinks, shore excursions and onboard spa services are typically billed separately.

How far in advance should I book this cruise?

For popular sailings, booking 6–12 months ahead typically gives the best cabin selection and fares. Last-minute discounts can appear 30–60 days before departure when the cruise line wants to fill remaining cabins on Seven Seas Grandeur.

What documents do I need to board?

Most international itineraries require a passport valid for at least six months beyond your return date. Closed-loop sailings that depart and return to the same U.S. port from Panama City, Panama may accept a government-issued photo ID plus a certified birth certificate for U.S. citizens — always verify with the cruise line.

Can I change or cancel my booking?

Change and cancellation policies depend on Regent Seven Seas Cruises's fare type and how close you are to departure. Refundable deposits typically allow changes up to the final-payment date without penalty; closer to sailing, cancellation fees scale up. Review the specific fare rules before booking.

What is a 22-night cruise like?

A 22-night cruise balances relaxing sea days with active port days. You can expect a mix of onboard programming — dining, entertainment, spa and fitness — and multiple shore excursions from Seven Seas Grandeur. Pack for both formal nights and casual deck days.

Seven Seas Grandeur 22-night Journey to the Amazon - Panama City to Panama City from Panama City, Panama, Mar 9, 2027

Regent Seven Seas Cruises · Seven Seas Grandeur · Mar 09, 2027 – Mar 31, 2027

Visit Panama City, Panama, Panama Canal, Oranjestad, Port of Spain, Macapa and 6 more ports

Departure Panama City, Panama

Return Panama City, Panama

Duration 22 Nights

From $25449 pp

Itinerary

Day 1

Panama City, Panama Arrives 12:00 AM · Departs 5:00 PM
Day 2

Panama Canal Arrives 6:00 AM · Departs 6:00 PM
Day 3

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 4

Oranjestad Arrives 10:00 AM · Departs 7:00 PM
Day 5

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 6

Port of Spain Arrives 7:00 AM · Departs 3:00 PM
Day 7

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 8

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 9

Macapa Arrives 10:00 AM · Departs 11:00 AM
Day 10

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 11

Manaus Arrives 7:00 AM · Departs 12:00 AM
Day 12

Manaus Arrives 12:00 AM · Departs 4:00 PM
Day 13

Boca Da Valeria Arrives 10:00 AM · Departs 5:00 PM
Day 14

Alter Do Chão (Amazon), Brazil Arrives 7:00 AM · Departs 3:00 PM
Day 15

Macapa Arrives 1:00 PM · Departs 2:00 PM
Day 16

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 17

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 18

St. Georges, Grenada Arrives 11:00 AM · Departs 6:00 PM
Day 19

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 20

Willemstad Arrives 7:00 AM · Departs 2:00 PM
Day 21

At Sea Arrives 12:00 AM · Departs 12:00 AM
Day 22

Transit Panama Canal Arrives 12:00 AM · Departs 12:00 AM
Day 23

Panama City, Panama Arrives 7:00 AM · Departs 12:00 AM

Cabin Prices

Prices as of 2026-10-19.

Prices per person, based on double occupancy in USD.

Suite $25449

Ports of Call

Panama City, Panama
Panama Canal
Oranjestad
Port of Spain
Macapa
Manaus
Boca Da Valeria
Alter Do Chão (Amazon), Brazil
St. Georges, Grenada
Willemstad
Transit Panama Canal

About This Cruise

22-night Regent Seven Seas Cruises Seven Seas Grandeur cruise from Panama City, Panama to Panama Canal, Oranjestad, Port of Spain and Macapa Compare…

Cruise Line Regent Seven Seas Cruises

Ship Seven Seas Grandeur

Frequently asked questions

What is included in the cruise fare?: Standard cruise fares include your cabin, onboard meals at main dining venues, most non-specialty entertainment, use of pools and common facilities, and transport between ports of call. Gratuities, specialty dining, alcoholic drinks, shore excursions and onboard spa services are typically billed separately.
How far in advance should I book this cruise?: For popular sailings, booking 6–12 months ahead typically gives the best cabin selection and fares. Last-minute discounts can appear 30–60 days before departure when the cruise line wants to fill remaining cabins on Seven Seas Grandeur.
What documents do I need to board?: Most international itineraries require a passport valid for at least six months beyond your return date. Closed-loop sailings that depart and return to the same U.S. port from Panama City, Panama may accept a government-issued photo ID plus a certified birth certificate for U.S. citizens — always verify with the cruise line.
Can I change or cancel my booking?: Change and cancellation policies depend on Regent Seven Seas Cruises's fare type and how close you are to departure. Refundable deposits typically allow changes up to the final-payment date without penalty; closer to sailing, cancellation fees scale up. Review the specific fare rules before booking.
What is a 22-night cruise like?: A 22-night cruise balances relaxing sea days with active port days. You can expect a mix of onboard programming — dining, entertainment, spa and fitness — and multiple shore excursions from Seven Seas Grandeur. Pack for both formal nights and casual deck days.